Medical Human microbiome

People in the modernized culture facing health disaster due to the collapse of microbial diversity in the gut microbiome. There is growing evidence that autoimmune diseases, including allergies, asthma, inflammatory bowel disorders, diabetes, etc … may be associated with changes in the gut microbiome. Recent generations see epidemics of these diseases. Arguments made by Martin Blazer in his book “Missing microbes” is the root of this crisis is that we are losing species diversity in the gut microbiome in. In fact, experiments Louis Pasteur support the germ theory of disease people have waged war on microbes. At first this was through surface application of antibiotics to kill microbes to prevent their spread; later (1930) sulfonamides drugs were developed to kill bacteria in the human body. In 1940 penicillin was developed to kill bacteria, and since then, antibiotics have been the main weapon used by people to kill bacteria in the body.

Most children born in the years after the development of antibiotics were provided with row after row of antibiotics in childhood to manage sore throat, ear infections and various diseases of childhood. With each series of antibiotic treatments for bacterial diversity in the gut microbiome was lost. Loss of diversity in the human gut microbiome should be inconsequential if the human bowel function only food the digestive organs. It now appears that this view of the human gut is not true or only partially correct. In fact, we now have evidence that the human gut, the largest organ in the body, can be viewed as “symbio-organ”, in symbiosis with microbes is a critical factor in its activities. The symbio organs gut functions to digest food, provide individual nutritional vitamins, detoxifying phytochemicals, inhibit pathogen virulence, develop nervous system, and equally important is the role that prime the immune system with constant exposure potential pathogens hold the immune system focused on microbes rather than himself. The human gut symbio organ is actually a complex organ with many features that affect the body in many ways and not simple digestive system that we envisioned first.

What consequences arising from the loss of microbial diversity in symbio target organ stomach? In terms of immune response, loss of diversity of microorganisms means that the body is not primed with antigen from a full compliment of gut microbes and rather than focusing the immune response to keep the gut microbes in check in symbio-organ, the body develops auto-immune problems, allergies, asthma, Crohn’s disease, etc … The loss of microbial diversity also means that potential agents of disease such as Clostridium difficile that live in the intestines may encourage disease. It seems clear that a diverse gut microbial communities have the ability to suppress virulence of potential pathogens in the gut. Exactly how microbes suppress virulence other microorganisms is not clear if some Evidence suggests organic acids (such as lactic acid, Propionic acid) likely virulence suppressors gastrointestinal tract. Changes in organic acid composition are often seen at the same time cases of intestinal diseases in Irritable bowel disease (IBD). Has been shown to suppress inflammation acid active outbreaks and butyric acid producing bacteria are examined as potential probiotics to control IBD and similar diseases. Which provides vitamins intestinal bacteria appear to be the principle source of biotin and vitamin K, both essential nutrients in our body.

Where is the gut microbiome come from? It is generally believed that humans inherit microbiome us from our mother. This is only partially true-but we know that we can rebuild a microbiome when it is damaged using fecal transplant and probiotics individual microbes. It is also true that plants contain large populations of microbes on their surface (as epiphytes) and embedded in their tissues (which endophytes). Some of the plant organisms are identical to those found in the human gut communities. Endophytic and epiphytic microorganisms colonize all parts of the plant leaves, stems, flowers and seed-the most diverse communities are found in the roots of plants. The plant root is actually another symbio organ that connects with microorganisms in the narrow area (rhizosphere) around the foot in the process of absorption of nutrients from the soil. The plant root is equivalent in terms of intestinal absorption function and works closely with a diverse community of microorganisms. Much of the plant foods majority of us consume in our diet from root crops-sweet potatoes, carrots, turnips, radishes, cassava, etc … A large variety of microbes could enter the gut microbiome in these plant foods, especially root crops. However, modern men cook most plants and processed our foods are mostly sterilized and free of potential microbiome residents. Because of this food processing plant intake in organisms from plants is very limited. Only highly resistant endopore formers (such as Bacillus or Clostridium) that may survive cooking or sterilization processes could enter the gut microbiome in.

How do we heal the human microbiome? The solution for mankind is to radically change what we eat and how we prepare it for consumption. Wherever possible we should consume plant foods (leaves, flowers, fruits, seeds, roots, tubers) uncooked and unpeeled protect diverse population of microbes living on them and within them. We should consume plants grown organically to maximize microbial diversity. We need to change, not just what we eat, but also what we feed our children. Baby food now been completely sterile segmented than ‘microbiome building’ baby food may have to be made from fresh plants with bacteria intact, or freeze dried with preserved organisms. Currently, we count also cook plants to soften and break down toxins-future new varieties of plants selected for raw edibility and high healthy diverse population of microorganisms could develop. Consumption of these new “probiotic crops’ could make it easy for people to redevelop and maintain healthy microbiome. The great battle of microorganisms in must end. When we reacquire diverse our gut microbiome-our guts symbio organs will start functioning properly again and epidemics of allergies, asthmas, inflammatory bowel disease and other autoimmune diseases problems can simply disappear.

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